3 ms·
The S. “Its own bill for landmark trialS of a four-drug combination treatment for drug-resistant tuberculosis came to €34m (£29m)” You’re also looking at the
by Retric 3y ago
The S.
“Its own bill for landmark trialS of a four-drug combination treatment for drug-resistant tuberculosis came to €34m (£29m)”
You’re also looking at the cost from from 2015 to 2016 where a single phase 3 trial was already 20m and $41,117 per patient. https://www.linkedin.com/pulse/clinical-trial-budget-example-patricio-ledesma https://www.linkedin.com/pulse/clinical-trial-budget-example...
- nickff 3y agoI don’t understand the difference you’re trying to point out. You’re both talking about the total cost for a testing a combination of drugs which required multiple phases, each of which is deemed a different trial. Am I wrong? What difference are you trying to highlight with the “s”?
- Retric 3y agoEach of those different phases would have cost ~26 million (30% inflation on 2015 prices).
- cameldrv 3y agoThe super high clinical trial costs also mean problems for any drug that isn't expected to have a large effect size, because it's hard to get statistical significance. Some trials have been controversially going for a surrogate endpoint, which makes the stats easier since you can get a continuous variable instead of a binary one, but that's also how you get aducanumab, which reduces amyloid plaque, but it's unclear if it actually helps in alzheimers. Despite this they charge $56k a year.