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You can set your main drive to the letter A or B, if it truly bothers you.

• paulmooreparks 3y ago
  Of course, if you do, be prepared for a lot of software to break because it's hard-coded to use "C:" and not actually use the APIs or environment variables to find the system drive location, user files location, etc. A lot of what gets blamed on Microsoft is really down to poor third-party software. Microsoft goes to extremes to keep that stuff running.