I do think it has a lot to do with the framework you enter with and how you understand what's happening, which I think is what OP was getting at. My most profou

I do think it has a lot to do with the framework you enter with and how you understand what's happening, which I think is what OP was getting at. My most profound experience was a full depersonalization, which I never even began to consider was a bad thing at all, but maybe for someone else would be filled with panic and anxiety. So it's all dependent on your view, which is probably why Buddhism puts 'right view' (samyak-drishti) as the first of the eight-fold path (although I don't think the ordering really matters, it's just convention).