Yes. Here is an example how to integrate Python to React front end https://blog.pyodide.org/posts/react-in-python-with-pyodide/ https://blog.pyodide.org/posts/

Yes. Here is an example how to integrate Python to React front end https://blog.pyodide.org/posts/react-in-python-with-pyodide/ https://blog.pyodide.org/posts/react-in-python-with-pyodide/ Similar examples for raw DOM manipulation should be available for Pyodide as well. It has bindings to all JS code, so it can do everything that JS can do.