4 ms·

I feel like this is a messaging roll out? https://www.medpagetoday.com/opinion/faustfiles/109672 https://www.medpagetoday.com/opinion/faustfiles/109672 -- an i

I feel like this is a messaging roll out? https://www.medpagetoday.com/opinion/faustfiles/109672 https://www.medpagetoday.com/opinion/faustfiles/109672 -- an interview from 2 days ago where the NIH leader says covid is persistent for months or years in people and the MD interviewer did a double take. Not sure why there's a shift happening, maybe some new publication? This has been shaping up for years now.

greyface- 2y ago
The relevant bit of transcript: Faust: I just want to follow up on something you said a moment ago about where this virus can be found in tissues. Are you suggesting that long COVID is actually, the mechanism of that, is persistent live virus in humans? Bertagnolli: We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI [gastrointestinal] tract, to the lung. Faust: OK. And you're saying this goes beyond the PCR's [polymerase chain reaction test] ability to get it in a regular swab so that we are missing chronic cases of SARS‑CoV‑2? Bertagnolli: Correct. The virus can persist in tissues for months, perhaps even years. Faust: OK. I think that's certainly one theory, but I'm not sure that that's settled. Is that fair? I mean, there's one thing between people who are autopsy, they died of viral sepsis, as opposed to people walking around. Is there a distinction there? Bertagnolli: Our emerging data shows that the virus can persist into tissues in the long term, and I think that's really critical because it does help us think about possible ways to combat it, one being better antivirals. I think there's a lot of focus on developing new antivirals as a possible way of preventing long COVID, and the other might be more aggressive treatment with antiviral therapy upon initial diagnosis. Faust: If that's the case, then it could be reactivated just like herpes is and shingles. Are we going to start seeing people get COVID not from infection, but from themselves in reactivation? Bertagnolli: I don't believe I've seen or heard of any instance of that, and I don't think you can ever assume that one virus is going to act like another. Certainly every virus that we know of seems to have a different effect in the body long term.

greyface- 2y ago

The relevant bit of transcript: Faust: I just want to follow up on something you said a moment ago about where this virus can be found in tissues. Are you suggesting that long COVID is actually, the mechanism of that, is persistent live virus in humans? Bertagnolli: We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI [gastrointestinal] tract, to the lung. Faust: OK. And you're saying this goes beyond the PCR's [polymerase chain reaction test] ability to get it in a regular swab so that we are missing chronic cases of SARS‑CoV‑2? Bertagnolli: Correct. The virus can persist in tissues for months, perhaps even years. Faust: OK. I think that's certainly one theory, but I'm not sure that that's settled. Is that fair? I mean, there's one thing between people who are autopsy, they died of viral sepsis, as opposed to people walking around. Is there a distinction there? Bertagnolli: Our emerging data shows that the virus can persist into tissues in the long term, and I think that's really critical because it does help us think about possible ways to combat it, one being better antivirals. I think there's a lot of focus on developing new antivirals as a possible way of preventing long COVID, and the other might be more aggressive treatment with antiviral therapy upon initial diagnosis. Faust: If that's the case, then it could be reactivated just like herpes is and shingles. Are we going to start seeing people get COVID not from infection, but from themselves in reactivation? Bertagnolli: I don't believe I've seen or heard of any instance of that, and I don't think you can ever assume that one virus is going to act like another. Certainly every virus that we know of seems to have a different effect in the body long term.