3 ms·
Neuroinflammation is a poorly studied area and one likely cause of brain fog and mecfs/long covid symptoms. Jarred Younger [1] is a researcher studying this and
by npunt 2y ago
Neuroinflammation is a poorly studied area and one likely cause of brain fog and mecfs/long covid symptoms. Jarred Younger [1] is a researcher studying this and has a youtube channel [2] where he discusses his latest work. If you're interested in this it's worth watching!
Also please ignore anyone that posts 'oh its just X' or 'just do X', whatever X may be. This is a complicated medical mystery that millions of patients have suffered from for decades if you include mecfs and postviral conditions. There is no X, patients have tried every possible X. Anyone who tells you its just X is revealing their lack of understanding of the issue (this happens every time this subject shows up on HN and elsewhere).
[1] https://me-pedia.org/wiki/Jarred_Younger https://me-pedia.org/wiki/Jarred_Younger
[2] https://www.youtube.com/channel/UCoVoOvIX90IMEZCbBf_ycEA https://www.youtube.com/channel/UCoVoOvIX90IMEZCbBf_ycEA
- ImHereToVote 2y agoWasn't there a paper that proposed the idea that long Covid is actual replicating virus that replicates in very low numbers.
- npunt 2y agoViral persistence is one theory that may explain a subset of long covid and other postviral cases (mecfs example [1]). There's lots of theories including itaconate shunt [2] and metabolic trap [3], glutamate toxicity [4], cranio-cervical instability and infections causing breakdown of tendons [5], gut biome imbalances [6][7], endothelial damage, and others. I'm not sure what the most promising ones are but the search for biomarkers continues. What we call long covid or mecfs or chronic lyme or fibromyalgia etc etc are all umbrella terms for symptom clusters so they lack some specificity and are likely multi-causal. There are many overlaps in LC and mecfs patient populations in studies (vs controls), so its likely a fair-to-significant amount of LC is actually what we call mecfs. Much of the mystery and suffering of long covid would have been avoided if we'd invested anything in investigating these conditions pre-covid (mecfs has the least funding to disease burden and the worst quality of life of all major diseases), but the medical community generally didn't want to believe these diseases were real. Same thing happened with autoimmune conditions like lupus and MS before their mechanisms were discovered. All of these conditions predominately affect women. [1] https://me-pedia.org/wiki/Persistent_infection_hypothesis https://me-pedia.org/wiki/Persistent_infection_hypothesis [2] https://me-pedia.org/wiki/Itaconate_shunt_hypothesis https://me-pedia.org/wiki/Itaconate_shunt_hypothesis [3] https://me-pedia.org/wiki/Metabolic_trap https://me-pedia.org/wiki/Metabolic_trap [4] https://me-pedia.org/wiki/Glutamate https://me-pedia.org/wiki/Glutamate [5] https://me-pedia.org/wiki/Craniocervical_instability https://me-pedia.org/wiki/Craniocervical_instability [6] https://me-pedia.org/wiki/Microbiome https://me-pedia.org/wiki/Microbiome [7] https://www.remissionbiome.org/ https://www.remissionbiome.org/