That might be nice if someone would do it and teach others to use it. Some labs have an RDBMS-based pipeline with published algorithms and data that nobody want

That might be nice if someone would do it and teach others to use it. Some labs have an RDBMS-based pipeline with published algorithms and data that nobody wants to try to reimplement (and which nobody would be paid to do). About the best improvement we could get was moving from an ancient version of MySQL to Postgres + PostGIS. I think Timescale would have helped. There were other reasons also to run locally due to privacy, cluster access, funds etc.