7 ms·

Good news against dengue

172 points by jseliger 3y ago

worldwidelies 3y ago
I got dengue and typhoid fever at the same time. They call it a co-infection. I was pissing blood at one point but they said it was due to dehydration and having a kidney stone I wasn't aware of until they had me get an ultrasound. Anyway, these types of viruses are unavoidable. Everyone gets sick from time to time. Incase anyone is curious, I got them both from a restaurant I went to. I kept getting bit by mosquitos that night and the water they served didn't taste right. I only took a few sips of the water but that's all you need to catch typhoid. I google mapped the restaurant and found a few open drainage ditches next to the restaurant. The mosquitos must have been growing in there.
benchgoblin 3y ago
Dengue can also be forecast with reasonable accuracy, particularly in countries like Brazil with good data systems https://www.biorxiv.org/content/10.1101/2024.03.12.584724v1 https://www.biorxiv.org/content/10.1101/2024.03.12.584724v1 (disclosure: I'm an author on this)
chupchap 3y ago
Oh this is amazing news. Dengue infection is common in parts of India I come from and there is very little that can be done about it beyond the basics. My parents have got it couple of times and it is similar to long covid in the sense that there is extreme body pain and a slow recovery.
marc_abonce 3y ago
For anyone wondering (because title is clickbaity): Two new dengue vaccines were recently announced by the Takeda and Butantan companies. Takeda: https://www.takeda.com/newsroom/newsreleases/2023/Takeda-Dengue-Vaccine-Recommended-by-World-Health-Organization-Advisory-Group-for-Introduction-in-High-Dengue-Burden-and-Transmission-Areas-in-Children-Ages-Six-to-16-Years/ https://www.takeda.com/newsroom/newsreleases/2023/Takeda-Den... Butantan: https://www.nejm.org/doi/full/10.1056/NEJMoa2301790 https://www.nejm.org/doi/full/10.1056/NEJMoa2301790
- EdwardDiego 3y ago
  It's just a blog post, and it is indeed good news. The author doesn't really need to bait any clicks.
- acoster 3y ago
  Butantan is not a company, but a public research institute run by the Brazilian state of São Paulo.
- weinzierl 3y ago
  In addition to that it is relevant because Dengue cases are at an all-time currently.
resolutebat 3y ago
A few years ago I had dengue in Singapore, and while my case was mild as far as these things go, I was still almost hospitalized because my platelet counts dropped so low. The overall experience was sufficiently unpleasant that I was strongly incentivized to take Dengvaxia, the only currently approved vaccine, but having gone through the process, I can see why very few people do. - As mentioned in the article, if you have never had dengue and you take Dengvaxia, it paradoxically increases the odds of getting a bad case. So in Singapore you're only eligible if you have had a confirmed positive blood test for dengue previously. - I had incredibly good health insurance at the time, which among other things happily paid for my dengue management at one of the best private hospitals in the country ($$$), but they straight up refused to cover Dengvaxia and I had to pay over $700 out of pocket. - Getting the vaccine required 3 shots spaced several months apart. Not a huge problem for me, and side effects were minor to non-existent (much better than eg COVID vaccines), but obviously this reduces compliance. - Even in Singapore, which is a wealthy, dense tropical country with a lot of dengue and thus eligible people, the hospital (again, one of the largest and best-resourced in the country) had to special order the vaccine every time for my three visits and there were a couple of minor hiccups with deliveries etc. My reward for all this is not immunity to future cases of dengue (remember, there are 5 serotypes and getting it once only makes you immune to that variety), but a 80% reduction in the odds of getting severe dengue the next time around. Which is nice, but not a game-changer.
- delta_p_delta_x 3y ago
  > one of the best private hospitals in the country ($$$) It's possible you might've gotten faster, better, and cheaper treatment at the Communicable Disease Centre which might already have had a stock of Dengvaxia. Like you said, dengue is endemic to Singapore, and most people who get it go there to get treated, rather than the (very expensive) private hospitals.
  - resolutebat 3y ago
    My understanding is that the unsubsidized cost of the three vaccine doses is on the order of $600, so the markup was pretty minimal here. (IIRC my insurance did cover the initial consultation re: the vaccine and the nurse fees.)
lxgr 3y ago
Oh, Qdenga already seems to be authorized for use in the EU, I completely missed that! Dengue has always been on my mind when traveling to SE Asia. A real shame that the FDA is dragging its feet once again.
- weinzierl 3y ago
  From all I know it is pretty hard to get over here, if you cannot prove you already had an infection. This is because the official recommendation seems to be against Qdenga for so called "Dengue-Natives". While it technically makes sense it is also not a very practical policy since most primary infections are asymptomatic or mild. Since you most likely don't know if you already had it, your doctor doesn't know if you benefit from Qdenga and will most likely stick to the official recommendation.
  - eru 3y ago
    Are you sure it's dengue-native, not dengue-naives?
  - Sakos 3y ago
    Doesn't this only apply to Dengvaxia? I can't find anything that states that Qdenga should only be used with people who've already been infected before. I also can't find anything stating there's a risk of ADE (antibody-dependent enhancement) with Qdenga as there is with Dengvaxia, which would make such a limitation necessary. https://www.takeda.com/newsroom/newsreleases/2022/takedas-qdenga-dengue-tetravalent-vaccine-live-attenuated-approved-for-use-in-european-union/ https://www.takeda.com/newsroom/newsreleases/2022/takedas-qd... https://www.ema.europa.eu/en/medicines/human/EPAR/qdenga https://www.ema.europa.eu/en/medicines/human/EPAR/qdenga https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement
zac23or 3y ago
Dengue is not a tropical disease. That does not exist. Dengue is a disease of bad governments. In Brazil, the majority of the population does not have sewage. Tap water is not potable and is not distributed every day, in some areas twice a week, in some areas less than that. This creates the need for everyone to have a water tank at home, creating the possibility of a large number of mosquito breeding sites. And the Moskito Aedes aegypti is a terrible vector of 52 diseases [0], among which it transmits a sarcoma (!!!) among hamsters. The current government tried not to buy vaccines[1], trying to wait for the Butantan vaccine. The current Brazilian government is the same or worse (!) than the previous one, more censorship, more dead Indians[2], more fires in the Amazon rainforest[3], and one thing is really worse: all the press covers up the mistakes of the current government . And...politicians are crazy, intelligent, incredible psychopaths. In the last two weeks the discussion has been about freedom of expression, about Elon Musk and so on. Economy, education, security and health are never priorities. It's clear that the government is trying to pass a law to regulate social media (and using Musk and Twitter as an example to do so), and the mainstream press is very eager to do so, because the law has a part that states that social media will pay for links to news sites. It is not a problem for a country that needs sewage. They are incredibly good at doing nothing. Some things in Brazil have been discussed for over 100 years, an example is a tunnel in the city of Santos[5]. The next government will also be bad, the population will fight over policies and nothing will change. I will never understand why people fight for these psychopaths. "My psychopath is better than yours." Please, I will not discuss “fascists” or “communists”, left or right, “everything is politics”, “but billionaires are bad”, etc. These are first-world problems. It is irrelevant for a country that needs sewage. Of course this can be discussed, but not in the current proportion. Sewers are much more important than that. [0] https://en.wikipedia.org/wiki/Aedes_aegypti#Vector_of_disease https://en.wikipedia.org/wiki/Aedes_aegypti#Vector_of_diseas... [1] https://saude-ig-com-br.translate.goog/2023-07-03/dengue-ministerio-da-saude-prioriza-produto-nacional-e-vacina-pode-ficar-para-2025 https://saude-ig-com-br.translate.goog/2023-07-03/dengue-min... .html?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [2] https://g1-globo-com.translate.goog/jornal-nacional/noticia/2024/02/23/mortes-de-indigenas-yanomami-em-2023-crescem-6percent-em-relacao-a https://g1-globo-com.translate.goog/jornal-nacional/noticia/... -2022-showm-dados-do-ministerio-da-saude.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [3] https://umsoplaneta-globo-com.translate.goog/biodiversidade/noticia/2024/04/11/incendios-em-areas-de-florestas-maduras-cresceram-152percent-na-amazonia-em-2023 https://umsoplaneta-globo-com.translate.goog/biodiversidade/... -aponta-estudo.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [4] https://g1-globo-com.translate.goog/sp/santos-regiao/noticia/2023/08/11/tunel-santos-guaruja-idealizado-ha-quase-100-anos-e-incluido https://g1-globo-com.translate.goog/sp/santos-regiao/noticia... -no-novo-pac.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [5] https://g1-globo-com.translate.goog/sp/santos-regiao/noticia/2023/08/11/tunel-santos-guaruja-idealizado-ha-quase-100-anos-e-incluido https://g1-globo-com.translate.goog/sp/santos-regiao/noticia... -no-novo-pac.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp
lawgimenez 3y ago
Our health officials really fucked it up with Dengvaxia back then. This was also the reason why there is still some vaccine hesitancy here especially with Dengue. I’m not sure how the government can make amends with the population. https://www.pharmaceutical-technology.com/features/dangvaxia-philippines/ https://www.pharmaceutical-technology.com/features/dangvaxia...
- bananatype 3y ago
  [dead]
objektif 3y ago
I posted about this last year. This will soon be an issue in the US as well and only then people will start freaking out. Because dengue can mess up anyone not just the old. Time to wipe out disease carrying mosquitos!!
- mattmaroon 3y ago
  Bill Gates has dozens of projects combating mosquitoes, at least one of which is intended to replace them with non-carrying mosquitoes. That’s what happens in America when we freak out now, one of the billionaires fixes it.
  - fragmede 3y ago
    In 2009, Bill Gates gave TEDTalk in which he released mosquitoes to make a point about malaria.
  - khaomungai 3y ago
    Read about Oxitec[1] a while ago and found their approach quite interesting! [1]https://www.oxitec.com/ https://www.oxitec.com/
    - objektif 3y ago
      This looks promising. How effective has it been in reality?
      - mattmaroon 3y ago
        It’s early. Studies in Brazil show up to 90% reduction (Oxitec’s numbers) and they’re just now going into their third season of testing in the Florida keys, working with the EPA. They say the results are good, and I assume they must be if the government is letting them expand the trials. I think we’ll have hard numbers soon. I’ve been following this for years just out of curiosity. It’s a brilliant solution and a brilliant business model. Because the genetic alteration kills the mosquitoes, you have to keep buying them from the company. It both makes it so that there’s seemingly little risk to the environment and subscription revenue.
Slava_Propanei 3y ago
[dead]
yosito 3y ago
I live in Thailand, and I've never had Dengue. I'm thinking about traveling to Bangkok for a Qdenga shot. Even though ADE doesn't seem to be a concern, I have gotten quite paranoid about any injections that trigger the immune system as I've now had allergic reactions to both vaccines and antibiotics. So I feel a little bit nervous about it.
- ankur3 3y ago
  My neighbour suffered paralysis after vaccine shot! Someone from known also suffered brain-stroke! My uncle died of cardiac arrest a year ago! I had seen lot of such stories around the world, yet an industry is moving forward to further increase all such activities, which doesn't seem right!
  - defrost 3y ago
    My neighbour suffered brain-stroke after a haircut! Someone else fell over and broke their arm also after a haircut! Some country like Australia with decades and decades of high quality medical records going back to the 1960s would surely show a huge increase in heart attacks and brain strokes after almost all of their 22+ million people had more than one vaccine and yet there were no significant increases in total stroke numbers! And yet many people had strokes, fell over, got hit by cars after having vaccine! How can this be??
    - deleted 2y ago
      [deleted]
    - ankur3 2y ago
      When authority denies tracking such data, you can ignore/mock for the lack of evidence! But does that help? My team had collected around 18000 such cases nationwide where people had reported, but instead of serious investigation, we saw no mention of this in mainstream media and social media reveals this is a worldwide problem! More people are getting vocal about this day by day! Hope public will soon understand what's happening!
ghostDancer 3y ago
Someone should sent this news to Argentinian government so they do something about the problem they're having right now instead of looking the other way. https://www.theguardian.com/global-development/2024/apr/12/i-felt-pains-all-over-my-body-argentina-battles-dengue-outbreak-as-politicians-pass-up-vaccine-opportunity https://www.theguardian.com/global-development/2024/apr/12/i...
- sofixa 3y ago
  > Someone should sent this news to Argentinian government so they do something about the problem they're having right now instead of looking the other way They aren't looking away, they're slashing costs everywhere without much thought and hiding their heads in the sand to any potential consequences. What more could you expect from a libertarian who gets advice from his dead dog?
  - goodrubyist 3y ago
    They really don't have any money.
    - sofixa 3y ago
      They don't have lots of money, that's for sure. But "saving" money by doing slashing costs on things which will literally cost you much more money in the short to mid term (like the whole dengue epidemic, for which prevention was cut, resulting in many more cases resulting in lots of healthcare costs and lost productivity) is not a way to govern a country. Using a different form of mismanagement to "fix" a mismanaged country doesn't really help.
  - ghostDancer 3y ago
    I know. He just wants to destroy everything so he can rebuild his libertarian paradise along his his tarot reader sister.
    - selimthegrim 3y ago
algesten 3y ago
I've spent lots of time in India. It's good to learn what the mosquito that can carry Dengue looks like. They are smaller and fly much faster and more erratically than a common mosquito – way harder to swat! If they settle down, you can see white stripes on their long legs and body. If you notice them, you can sometimes figure out why they are congregating, they need blood and standing still water to procreate. At one place I stayed, next door there was a construction site where the workers also slept bare skinned at the site. That's the only time I caught it. Another place I stayed was also seriously infested, I couldn't sit outside. I went looking and found two barrels of rain water on the roof, full of larvae. I added a small amount of dishwasher liquid to the barrels, which worked. Mosquitos went away in a few days.

172 points by jseliger 3y ago

I got dengue and typhoid fever at the same time. They call it a co-infection. I was pissing blood at one point but they said it was due to dehydration and having a kidney stone I wasn't aware of until they had me get an ultrasound. Anyway, these types of viruses are unavoidable. Everyone gets sick from time to time. Incase anyone is curious, I got them both from a restaurant I went to. I kept getting bit by mosquitos that night and the water they served didn't taste right. I only took a few sips of the water but that's all you need to catch typhoid. I google mapped the restaurant and found a few open drainage ditches next to the restaurant. The mosquitos must have been growing in there.

benchgoblin 3y ago

Dengue can also be forecast with reasonable accuracy, particularly in countries like Brazil with good data systems https://www.biorxiv.org/content/10.1101/2024.03.12.584724v1 https://www.biorxiv.org/content/10.1101/2024.03.12.584724v1 (disclosure: I'm an author on this)

chupchap 3y ago

Oh this is amazing news. Dengue infection is common in parts of India I come from and there is very little that can be done about it beyond the basics. My parents have got it couple of times and it is similar to long covid in the sense that there is extreme body pain and a slow recovery.

marc_abonce 3y ago

For anyone wondering (because title is clickbaity): Two new dengue vaccines were recently announced by the Takeda and Butantan companies. Takeda: https://www.takeda.com/newsroom/newsreleases/2023/Takeda-Dengue-Vaccine-Recommended-by-World-Health-Organization-Advisory-Group-for-Introduction-in-High-Dengue-Burden-and-Transmission-Areas-in-Children-Ages-Six-to-16-Years/ https://www.takeda.com/newsroom/newsreleases/2023/Takeda-Den... Butantan: https://www.nejm.org/doi/full/10.1056/NEJMoa2301790 https://www.nejm.org/doi/full/10.1056/NEJMoa2301790

EdwardDiego 3y ago
It's just a blog post, and it is indeed good news. The author doesn't really need to bait any clicks.
acoster 3y ago
Butantan is not a company, but a public research institute run by the Brazilian state of São Paulo.
weinzierl 3y ago
In addition to that it is relevant because Dengue cases are at an all-time currently.

resolutebat 3y ago

A few years ago I had dengue in Singapore, and while my case was mild as far as these things go, I was still almost hospitalized because my platelet counts dropped so low. The overall experience was sufficiently unpleasant that I was strongly incentivized to take Dengvaxia, the only currently approved vaccine, but having gone through the process, I can see why very few people do. - As mentioned in the article, if you have never had dengue and you take Dengvaxia, it paradoxically increases the odds of getting a bad case. So in Singapore you're only eligible if you have had a confirmed positive blood test for dengue previously. - I had incredibly good health insurance at the time, which among other things happily paid for my dengue management at one of the best private hospitals in the country ($$$), but they straight up refused to cover Dengvaxia and I had to pay over $700 out of pocket. - Getting the vaccine required 3 shots spaced several months apart. Not a huge problem for me, and side effects were minor to non-existent (much better than eg COVID vaccines), but obviously this reduces compliance. - Even in Singapore, which is a wealthy, dense tropical country with a lot of dengue and thus eligible people, the hospital (again, one of the largest and best-resourced in the country) had to special order the vaccine every time for my three visits and there were a couple of minor hiccups with deliveries etc. My reward for all this is not immunity to future cases of dengue (remember, there are 5 serotypes and getting it once only makes you immune to that variety), but a 80% reduction in the odds of getting severe dengue the next time around. Which is nice, but not a game-changer.

delta_p_delta_x 3y ago
> one of the best private hospitals in the country ($$$) It's possible you might've gotten faster, better, and cheaper treatment at the Communicable Disease Centre which might already have had a stock of Dengvaxia. Like you said, dengue is endemic to Singapore, and most people who get it go there to get treated, rather than the (very expensive) private hospitals.
- resolutebat 3y ago
  My understanding is that the unsubsidized cost of the three vaccine doses is on the order of $600, so the markup was pretty minimal here. (IIRC my insurance did cover the initial consultation re: the vaccine and the nurse fees.)

lxgr 3y ago

Oh, Qdenga already seems to be authorized for use in the EU, I completely missed that! Dengue has always been on my mind when traveling to SE Asia. A real shame that the FDA is dragging its feet once again.

weinzierl 3y ago
From all I know it is pretty hard to get over here, if you cannot prove you already had an infection. This is because the official recommendation seems to be against Qdenga for so called "Dengue-Natives". While it technically makes sense it is also not a very practical policy since most primary infections are asymptomatic or mild. Since you most likely don't know if you already had it, your doctor doesn't know if you benefit from Qdenga and will most likely stick to the official recommendation.
- eru 3y ago
  Are you sure it's dengue-native, not dengue-naives?
- Sakos 3y ago
  Doesn't this only apply to Dengvaxia? I can't find anything that states that Qdenga should only be used with people who've already been infected before. I also can't find anything stating there's a risk of ADE (antibody-dependent enhancement) with Qdenga as there is with Dengvaxia, which would make such a limitation necessary. https://www.takeda.com/newsroom/newsreleases/2022/takedas-qdenga-dengue-tetravalent-vaccine-live-attenuated-approved-for-use-in-european-union/ https://www.takeda.com/newsroom/newsreleases/2022/takedas-qd... https://www.ema.europa.eu/en/medicines/human/EPAR/qdenga https://www.ema.europa.eu/en/medicines/human/EPAR/qdenga https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement

zac23or 3y ago

Dengue is not a tropical disease. That does not exist. Dengue is a disease of bad governments. In Brazil, the majority of the population does not have sewage. Tap water is not potable and is not distributed every day, in some areas twice a week, in some areas less than that. This creates the need for everyone to have a water tank at home, creating the possibility of a large number of mosquito breeding sites. And the Moskito Aedes aegypti is a terrible vector of 52 diseases [0], among which it transmits a sarcoma (!!!) among hamsters. The current government tried not to buy vaccines[1], trying to wait for the Butantan vaccine. The current Brazilian government is the same or worse (!) than the previous one, more censorship, more dead Indians[2], more fires in the Amazon rainforest[3], and one thing is really worse: all the press covers up the mistakes of the current government . And...politicians are crazy, intelligent, incredible psychopaths. In the last two weeks the discussion has been about freedom of expression, about Elon Musk and so on. Economy, education, security and health are never priorities. It's clear that the government is trying to pass a law to regulate social media (and using Musk and Twitter as an example to do so), and the mainstream press is very eager to do so, because the law has a part that states that social media will pay for links to news sites. It is not a problem for a country that needs sewage. They are incredibly good at doing nothing. Some things in Brazil have been discussed for over 100 years, an example is a tunnel in the city of Santos[5]. The next government will also be bad, the population will fight over policies and nothing will change. I will never understand why people fight for these psychopaths. "My psychopath is better than yours." Please, I will not discuss “fascists” or “communists”, left or right, “everything is politics”, “but billionaires are bad”, etc. These are first-world problems. It is irrelevant for a country that needs sewage. Of course this can be discussed, but not in the current proportion. Sewers are much more important than that. [0] https://en.wikipedia.org/wiki/Aedes_aegypti#Vector_of_disease https://en.wikipedia.org/wiki/Aedes_aegypti#Vector_of_diseas... [1] https://saude-ig-com-br.translate.goog/2023-07-03/dengue-ministerio-da-saude-prioriza-produto-nacional-e-vacina-pode-ficar-para-2025 https://saude-ig-com-br.translate.goog/2023-07-03/dengue-min... .html?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [2] https://g1-globo-com.translate.goog/jornal-nacional/noticia/2024/02/23/mortes-de-indigenas-yanomami-em-2023-crescem-6percent-em-relacao-a https://g1-globo-com.translate.goog/jornal-nacional/noticia/... -2022-showm-dados-do-ministerio-da-saude.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [3] https://umsoplaneta-globo-com.translate.goog/biodiversidade/noticia/2024/04/11/incendios-em-areas-de-florestas-maduras-cresceram-152percent-na-amazonia-em-2023 https://umsoplaneta-globo-com.translate.goog/biodiversidade/... -aponta-estudo.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [4] https://g1-globo-com.translate.goog/sp/santos-regiao/noticia/2023/08/11/tunel-santos-guaruja-idealizado-ha-quase-100-anos-e-incluido https://g1-globo-com.translate.goog/sp/santos-regiao/noticia... -no-novo-pac.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp [5] https://g1-globo-com.translate.goog/sp/santos-regiao/noticia/2023/08/11/tunel-santos-guaruja-idealizado-ha-quase-100-anos-e-incluido https://g1-globo-com.translate.goog/sp/santos-regiao/noticia... -no-novo-pac.ghtml?_x_tr_sl=pt&_x_tr_tl=en&_x_tr_hl=pt-BR&_x_tr_pto=wapp

lawgimenez 3y ago

Our health officials really fucked it up with Dengvaxia back then. This was also the reason why there is still some vaccine hesitancy here especially with Dengue. I’m not sure how the government can make amends with the population. https://www.pharmaceutical-technology.com/features/dangvaxia-philippines/ https://www.pharmaceutical-technology.com/features/dangvaxia...

bananatype 3y ago
[dead]

objektif 3y ago

I posted about this last year. This will soon be an issue in the US as well and only then people will start freaking out. Because dengue can mess up anyone not just the old. Time to wipe out disease carrying mosquitos!!

mattmaroon 3y ago
Bill Gates has dozens of projects combating mosquitoes, at least one of which is intended to replace them with non-carrying mosquitoes. That’s what happens in America when we freak out now, one of the billionaires fixes it.
- fragmede 3y ago
  In 2009, Bill Gates gave TEDTalk in which he released mosquitoes to make a point about malaria.
- khaomungai 3y ago
  Read about Oxitec[1] a while ago and found their approach quite interesting! [1]https://www.oxitec.com/ https://www.oxitec.com/
  - objektif 3y ago
    This looks promising. How effective has it been in reality?
    - mattmaroon 3y ago
      It’s early. Studies in Brazil show up to 90% reduction (Oxitec’s numbers) and they’re just now going into their third season of testing in the Florida keys, working with the EPA. They say the results are good, and I assume they must be if the government is letting them expand the trials. I think we’ll have hard numbers soon. I’ve been following this for years just out of curiosity. It’s a brilliant solution and a brilliant business model. Because the genetic alteration kills the mosquitoes, you have to keep buying them from the company. It both makes it so that there’s seemingly little risk to the environment and subscription revenue.

Slava_Propanei 3y ago

[dead]

yosito 3y ago

I live in Thailand, and I've never had Dengue. I'm thinking about traveling to Bangkok for a Qdenga shot. Even though ADE doesn't seem to be a concern, I have gotten quite paranoid about any injections that trigger the immune system as I've now had allergic reactions to both vaccines and antibiotics. So I feel a little bit nervous about it.

ankur3 3y ago
My neighbour suffered paralysis after vaccine shot! Someone from known also suffered brain-stroke! My uncle died of cardiac arrest a year ago! I had seen lot of such stories around the world, yet an industry is moving forward to further increase all such activities, which doesn't seem right!
- defrost 3y ago
  My neighbour suffered brain-stroke after a haircut! Someone else fell over and broke their arm also after a haircut! Some country like Australia with decades and decades of high quality medical records going back to the 1960s would surely show a huge increase in heart attacks and brain strokes after almost all of their 22+ million people had more than one vaccine and yet there were no significant increases in total stroke numbers! And yet many people had strokes, fell over, got hit by cars after having vaccine! How can this be??
  - deleted 2y ago
    [deleted]
  - ankur3 2y ago
    When authority denies tracking such data, you can ignore/mock for the lack of evidence! But does that help? My team had collected around 18000 such cases nationwide where people had reported, but instead of serious investigation, we saw no mention of this in mainstream media and social media reveals this is a worldwide problem! More people are getting vocal about this day by day! Hope public will soon understand what's happening!

ghostDancer 3y ago

Someone should sent this news to Argentinian government so they do something about the problem they're having right now instead of looking the other way. https://www.theguardian.com/global-development/2024/apr/12/i-felt-pains-all-over-my-body-argentina-battles-dengue-outbreak-as-politicians-pass-up-vaccine-opportunity https://www.theguardian.com/global-development/2024/apr/12/i...

sofixa 3y ago
> Someone should sent this news to Argentinian government so they do something about the problem they're having right now instead of looking the other way They aren't looking away, they're slashing costs everywhere without much thought and hiding their heads in the sand to any potential consequences. What more could you expect from a libertarian who gets advice from his dead dog?
- goodrubyist 3y ago
  They really don't have any money.
  - sofixa 3y ago
    They don't have lots of money, that's for sure. But "saving" money by doing slashing costs on things which will literally cost you much more money in the short to mid term (like the whole dengue epidemic, for which prevention was cut, resulting in many more cases resulting in lots of healthcare costs and lost productivity) is not a way to govern a country. Using a different form of mismanagement to "fix" a mismanaged country doesn't really help.
- ghostDancer 3y ago
  I know. He just wants to destroy everything so he can rebuild his libertarian paradise along his his tarot reader sister.
  - selimthegrim 3y ago

algesten 3y ago

I've spent lots of time in India. It's good to learn what the mosquito that can carry Dengue looks like. They are smaller and fly much faster and more erratically than a common mosquito – way harder to swat! If they settle down, you can see white stripes on their long legs and body. If you notice them, you can sometimes figure out why they are congregating, they need blood and standing still water to procreate. At one place I stayed, next door there was a construction site where the workers also slept bare skinned at the site. That's the only time I caught it. Another place I stayed was also seriously infested, I couldn't sit outside. I went looking and found two barrels of rain water on the roof, full of larvae. I added a small amount of dishwasher liquid to the barrels, which worked. Mosquitos went away in a few days.