I was wrong to bring up the blood brain barrier and the liver. My point is that an individual’s enzyme profile* is more relevant to dosing than whether or not t

I was wrong to bring up the blood brain barrier and the liver. My point is that an individual’s enzyme profile* is more relevant to dosing than whether or not they have ADHD, which seemed to me what you were implying here: > One friend (into recreation drugs) took 40mg > Another (prescribed) took 80mg You can take someone undiagnosed with ADHD, give them 80mg and they could possibly not feel a thing. Likewise there are those who are prescribed low doses like 2.5mg. It’s a pet peeve of mine the myths I’ve seen shared pervasively on SM: 1) getting high from a stimulant doesn’t preclude you from having ADHD. I know this is not what you said but I’ve read comments that literally state if you experience euphoria or other stimulating effects from Adderall, then you couldn’t have ADHD. That’s clearly not how ADHD is diagnosed. Therapeutic dose is all about minimizing those “side effects” 2) that certain people with ADHD cannot experience a stimulant high. That seems extremely dubious to me. Barring a higher dose of amphetamine or more straightforward meth, I’m sure if they can’t get it there then they could from MDA, MDMA, coke, DMT, mescaline, LSD or plain old THC… yes even from a psychedelic it’s a stimulant effect. It’s not the ADHD it’s the personal chemistry * said enzymes exist in the brain, too, of course, I didn’t know that till I googled more Edit: typo and format