Hey, my understanding is that they're initially targeting Japanese ~~elderly who have already lost their teeth~~ children who genetically forgot to grow at leas

Hey, my understanding is that they're initially targeting Japanese ~~elderly who have already lost their teeth~~ children who genetically forgot to grow at least 6 of their adult teeth (1 in 10k affected). (https://uniqa.dental/news/tooth-regeneration-drug-trials-in-japan/ https://uniqa.dental/news/tooth-regeneration-drug-trials-in-...) Also there are many people who have sustained teeth damage bad enough to normally warrant 2+ implants plus fillings for the others, and at that point, it's warranted to think about doing "wisdom teeth removal" for the remaining and growing a new set. It's obviously not suited for replacing a single lost tooth. Well, ferrets teeth are very close to humans, so it working for them is already highly suggestive of it working for humans. Then, the antibodies being human ones, and that they even work in mice that are very very different teeth-wise from humans, is enough to warrant trying in humans. This isn't considering the safety (no predicted collateral damage; the antibodies target USAG-1 which has purposes beyond teeth growth inhibition), but yeah. Also see https://www.popularmechanics.com/science/health/a44786433/humans-have-third-set-teeth/ https://www.popularmechanics.com/science/health/a44786433/hu... ....