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Note that GLP1 receptor agonists are a whole class of drugs, and they were known to be effective in treating diabetes as well, and have been for a while. Recen

Note that GLP1 receptor agonists are a whole class of drugs, and they were known to be effective in treating diabetes as well, and have been for a while. Recent commercialization and buzz is definitely new and there have been new formulations of course. It is quite remarkable that people might think simply telling people to "lose weight" will work still, in this day and age.

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arcticbull 2y ago
The reality is that insulin isn't a treatment for Type 2 -- it's a treatment for Type 1. Type 1 is basically internal starvation. Your cells can't obtain the glucose they need from your blood because your body can't produce insulin. Type 2 is the exact opposite. Your cells are saturated with glucose and your body literally can't produce any more insulin to stuff that glucose away. Giving insulin just forces the excess blood glucose into tissue and causes additional fat gain. The additional fat gain makes Type 2 worse. Weight loss is the treatment for Type 2. We've kind of known this since 1915 when Type 2 was treated with fasting. Right up until insulin was discovered. [1, 2, 3] That's why GLP-1/GIPs work for diabetes. They make you not hungry, so you don't eat, so you lose weight, and presto, no more insulin resistance. > [...] we now understand that people with type 2 diabetes who lose significant weight and improve other factors related to diabetes can achieve remission. [3] Fun fact. [1] https://www.endocrine.org/news-and-advocacy/news-room/2022/intermittent-fasting-may-reverse-type-2-diabetes https://www.endocrine.org/news-and-advocacy/news-room/2022/i... [2] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2811116 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... [3] https://www.niddk.nih.gov/health-information/professionals/diabetes-discoveries-practice/achieving-type-2-diabetes-remission-through-weight-loss https://www.niddk.nih.gov/health-information/professionals/d...

deleted 2y ago

[deleted]

arcticbull 2y ago

The reality is that insulin isn't a treatment for Type 2 -- it's a treatment for Type 1. Type 1 is basically internal starvation. Your cells can't obtain the glucose they need from your blood because your body can't produce insulin. Type 2 is the exact opposite. Your cells are saturated with glucose and your body literally can't produce any more insulin to stuff that glucose away. Giving insulin just forces the excess blood glucose into tissue and causes additional fat gain. The additional fat gain makes Type 2 worse. Weight loss is the treatment for Type 2. We've kind of known this since 1915 when Type 2 was treated with fasting. Right up until insulin was discovered. [1, 2, 3] That's why GLP-1/GIPs work for diabetes. They make you not hungry, so you don't eat, so you lose weight, and presto, no more insulin resistance. > [...] we now understand that people with type 2 diabetes who lose significant weight and improve other factors related to diabetes can achieve remission. [3] Fun fact. [1] https://www.endocrine.org/news-and-advocacy/news-room/2022/intermittent-fasting-may-reverse-type-2-diabetes https://www.endocrine.org/news-and-advocacy/news-room/2022/i... [2] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2811116 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... [3] https://www.niddk.nih.gov/health-information/professionals/diabetes-discoveries-practice/achieving-type-2-diabetes-remission-through-weight-loss https://www.niddk.nih.gov/health-information/professionals/d...