If the liver gets full of hard scar tissue, it can physically constrain the hepatocytes from making more liver tissue. https://www.news-medical.net/news/2020082

If the liver gets full of hard scar tissue, it can physically constrain the hepatocytes from making more liver tissue. https://www.news-medical.net/news/20200824/Large-animals-with-ailing-livers-can-grow-new-organ-in-lymph-nodes-from-their-own-hepatocytes.aspx https://www.news-medical.net/news/20200824/Large-animals-wit...