4 ms·
There are two reasons I can think of why that wouldn't happen: first, there's no primer to even initiate the reverse transcription. Maybe you might get unlucky
by jryb 3y ago
There are two reasons I can think of why that wouldn't happen: first, there's no primer to even initiate the reverse transcription. Maybe you might get unlucky and there's something close enough floating around. But integration machinery usually requires some specific sequence to identify the ends of the viral genome. Maybe that exists, it's not my field, but I've never heard of one.
Also, even if it did integrate, there would be no promoter, so the vaccine gene wouldn't get expressed. So the only danger I see would be if it integrated into something functional, but the virus was going to do that anyway. But this is so improbable to begin with I wouldn't worry about it.
- saalweachter 3y agoI believe there is some Crisper work going on to remove retroviruses from DNA. I think there was a promising trial recently with trying to strip HIV from someone's immune cells? AFAIK it's not mRNA-related technology.