I have yet to see any anti-scraping method that can protect against a full instance of Chrome automated with Sikuli. It's obviously very expensive to run, since

I have yet to see any anti-scraping method that can protect against a full instance of Chrome automated with Sikuli. It's obviously very expensive to run, since you either need dedicated boxes or VMs, but it always works. In my experience the most consistent parts of any web application are the text and widgets that ultimately render on the screen, so you easily make up for the runtime costs with reduced maintenance. You could in theory make a site that randomly changes button labels or positions, but to the extent you annoy scrapers you're also going to annoy your actual users.