The biggest problem is Garbage-In-Garbage-Out and your final analysis is only as good as your guesstimates for the initial probabilities. So initially the pres

The biggest problem is Garbage-In-Garbage-Out and your final analysis is only as good as your guesstimates for the initial probabilities. So initially the presence of the FCS in the SARS-CoV-2 genome was a "smoking gun" for the lab leak hypothesis way back in 2020 when the sequence was first released for a few days and people were just trying to digest the whole new reality. Now we've found FCS segments and near-FCS segments in other beta-coronaviruses and the FCS that SARS-CoV-2 has is a strange novel sequence that no human would have tried to put there. That has gone from something like 90% evidence for the lab leak to 99.9% evidence against it in the past 4 years.