I had a single game that, AFAICT, the CD-ROM version couldn't run on MS-DOS the normal way because the intro it showed needed more conventional memory that was

I had a single game that, AFAICT, the CD-ROM version couldn't run on MS-DOS the normal way because the intro it showed needed more conventional memory that was possible with mscdex loaded[1]. There was a workaround that consisted of running the program that would resume from the latest save, then exiting to the main menu. If you had a large enough hard-drive, you could also run it by copying the data to your hard drive, then manually pointing the game at the path (thus allowing you to omit the CD-ROM driver). I managed to get it to run off the CD by using the nwcdex (From Novell Dos 7, after Novell purchased Digital Research), which could load itself into EMS. 1: This was the CD-ROM version of Master of Magic. The intro needed approximately 630KB of conventional memory to run.