The FAA mandates that exits be distributed "as uniformly as practical" and requires certain numbers and types of exit according to the number of passengers [0]

The FAA mandates that exits be distributed "as uniformly as practical" and requires certain numbers and types of exit according to the number of passengers [0] Also, at max capacity all passengers and crew must be able to evacuate in 90 seconds [1]. So, your cargo experience might have regulatory trouble. The "as uniformly as possible" might allow for a blended wing design though, provided you could get everyone out fast enough. There might be some other relevant regulations that I've missed as well. [0] - https://www.law.cornell.edu/cfr/text/14/25.807 https://www.law.cornell.edu/cfr/text/14/25.807 [1] - https://www.law.cornell.edu/cfr/text/14/25.803 https://www.law.cornell.edu/cfr/text/14/25.803