So this piqued my curiosity as it reminded me of something I read regarding the differences btwn male and female myelination whereas the sheath develops in male

So this piqued my curiosity as it reminded me of something I read regarding the differences btwn male and female myelination whereas the sheath develops in males "from the inside out" and in females "from the outside in" I found this interesting when I heard it... But MS presents in females vs males at 3:1 according to the MS society. Whats interesting is this article from NIH >"Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination" [0] it discusses the enzyme-like activities of nanomaterials, specifically how the iron cores of biogenic ferritins act as natural nanozymes to scavenge superoxide radicals The first sentence is pretty unpackable to some interesting "huh." moments: Neuroprotective, anti-inflammatory, and remyelinating properties of androgens are well-characterized in demyelinated male mice and men suffering from multiple sclerosis. However, androgen effects mediated by the androgen receptor (AR), have been only poorly studied in females who make low androgen levels But the Stanford study identified SRF (serum response factor) as a pivotal regulator of the genes involved in the cellular structure of oligodendrocytes—the glial cells responsible for myelinating nerve fibers in the brain and spinal cord. The Nature study goes on about nanozymes and how they may be able to affect remelination. [1] This NIH study discusses the gender differences of presenting MS in male/female rats as it pertains to where MS markers are found, whereas in females its found in spinal, but in males in the cerebellum... So if the growth of myelin is different in females than males, the markers occur in a gender dependent manner, and MS presents 3:1 females - its the myelination's development order thats calling out for observation... I looked up the etymology of myelin - and intersingly: >’: The ‘my’ in ‘myelin’ comes from the Greek word ‘myelos’ which means ‘marrow’ or 'the innermost part’. So, ‘myelin’ refers to the soft material found in nerve tissues." So as it was mentioned that females develop from the outside in, and myelin is the innermost soft tissue in the nerve, and MS present in females 3:1 - is this just all coincidence or is it just me? - Anecdote. when my daughter was a toddler, we kept catching her getting into the fridge and eating gobs of butter. I called my grandmother a life-long surgical nurse to ask if this was odd. She said "Heck no! Let her do it. Her brain is telling her she needs fats for development. Its good for her brain" - Shes wicked smart now. (but Ill take credit for the genes :-) [0] - https://www.nature.com/articles/s41467-023-36846-w https://www.nature.com/articles/s41467-023-36846-w [1] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282645/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282645/