Well, we often deal with untestable questions in science, such as: what was the molecular pathway that led to the origin of life? Time has erased the data we'd

Well, we often deal with untestable questions in science, such as: what was the molecular pathway that led to the origin of life? Time has erased the data we'd need to test any hypothesis, thus even if we do create a living cell from simple elements, there's no way at all to be sure that was the route that life took. Hence we can't rule out some supernatural being jiggling the atoms about just so at the origin of life. So, even if we choose to believe in a purely mechanistic universe, we can't definitively test that hypothesis using the tools and methods of science. Practically, this means that the scope of science as a means for discovering the nature of reality is limited. edit: note that a reproducible glitch in the simulation would be of interest, and one could even argue that looking for such glitches is in part what scientists do.