In-vivo is hard but there are many talented teams working on this. In animals, a company called Verve has discovered how to make in vivo CRISPR work via nanopar

In-vivo is hard but there are many talented teams working on this. In animals, a company called Verve has discovered how to make in vivo CRISPR work via nanoparticles to the liver which achieves >80% delivery at certain concentrations of nanos. Pretty fascinating