As per the Nature paper, this is an immune system mechanism with these particular “fat” particles presumed to help fend off an invading microbe. So no, it doesn

As per the Nature paper, this is an immune system mechanism with these particular “fat” particles presumed to help fend off an invading microbe. So no, it doesn’t matter how much fat or not you have to begin with as you cannot as easily reduce the immune system ability to do its work, and even if you did somehow manage to stop this particular immune response it is far from clear if you would get more or less dementia as a result.