3 ms·
Can I ask you your thoughts about CYP21A2? Been studying folks with only one working CYP21A2 due to the resulting atypical adrenal function and I noticed that
by mobilejdral 3y ago
Can I ask you your thoughts about CYP21A2?
Been studying folks with only one working CYP21A2 due to the resulting atypical adrenal function and I noticed that their dna also contains all the genetic variants associated with Alzheimer's (some are beneficial in this case). Inquiring about the family tree of the single CYP21A2 I have yet to have someone tell me of an ancestor that died of Alzheimer's. But the family members with two good CYP21A2 (and all of the other typical Alzheimer's genetics) are the ones that end up with Alzheimer's. And for good measure, when someone has 3 CYP21A2 nearly always they will get Alzheimer's. (they also end up with Hypercortisolism).
Subclinical Hypercortisolism has a long association with Alzheimer's. A deficient CYP21A2 and the decreased incidences of Alzheimer's is not talked about other than the fact that it isn't associated with Subclinical Hypercortisolism, but Subclinical Hypocortisolism instead.
All of the known indirect early preventative measures for Alzheimer's result in shifting from Subclinical Hypercortisolism towards Subclinical Hypocortisolism.
This was not my intended area of study, but the pattern is interesting and curious for your thoughts.
- smeej 3y agoI'm really uninformed about this topic, but I'll second the request for info about this! I have Alzheimer's on three sides of my family (really banking on the fact that I take after the 4th grandmother who was sharp as a tack till 98), and while I haven't ever looked into a diagnosis of hypercorticolism, thanks to very early (in utero/neonate) trauma, my parasympathetic nervous system never learned how to clear cortisol like it should, which I'm working to remediate now. I've been operating under the assumption that Alzheimer's is a high risk in my future, but I'd love to know more about what any experts would say I could even try to do by lifestyle change or preventative treatment!
- saintlunaire 3y agoMay I ask how you found out your nervous system has trouble clearing cortisol? Is there a test you can do? How are you remediating it? I also have Alzheimer’s in the family and this hypercortisolism discussion feels familiar to me.
- daddylongstroke 3y agoAssuming your psychological state of mind and your heart health is relatively good, whole body cold water plunges/swimming 3 times a week for 2-3 minutes, has been shown (in relatively small studies) to have many positive effects on various endocrine system functions, including cortisol levels.
- DarknessFalls 3y agoI don't know if you've seen the documentary 'My Octopus Teacher', but the subject spends an entire year diving in frigid water. His voice and general presence are so peaceful, it's almost comical. I joked at the time I saw it that he must have no cortisol left.