3 ms·

There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in: 1) People with

There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in: 1) People with obesity 2) People with type 2 diabetes 3) People who do endurance exercise Even though #3 is highly protective against #1 and #2. The best explanation I've seen is that the important difference is why the lipid droplets are being deposited [1] [1] https://link.springer.com/article/10.1007/s00424-005-1509-0 https://link.springer.com/article/10.1007/s00424-005-1509-0

teaearlgraycold 3y ago
If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt. I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
- levocardia 3y ago
  Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
  - teaearlgraycold 3y ago
    Well yeah. You’re measuring the output to a multi-variate function. There should be no expectation that this one output drives other occasionally correlated outputs to other functions.
  - aulin 3y ago
    If I recall correctly there were some studies that actually showed endurance runners have higher type 2 diabetes risk. And the suspect cause was the diet, specifically the carb loading practice and the abuse of high sugar products during the activity. So the three categories may actually share the same baseline, insulin resistance. It was quite controversial when it emerged (see Tim Noakes story), not sure if it's more accepted these days.
    - lelanthran 3y ago
      This is very interesting to a diabetic like myself, who is slightly underweight. I've even had some people tell me I can't be diabetic because I don't have much, if any, extra fat.
trhway 3y ago
Doesn’t diabetes mean that the cells has to extract more energy from those lipid droplets instead of from the glucose pathway impacted by the diabetes? Thus in the cases of 2 and 3 those droplets is an additional significant source of energy. I also think that in the case of 1 the cells may be starving on glucose pathways (pre-diabetes), similar to 3 during the exercise and to 2 in regular situation, and that causes the over-eating while all that food doesn’t feed the cells because of the original issue and thus goes into fat for storage and into the lipid droplets way of feeding the cells to workaround the original glucose pathway issue.

teaearlgraycold 3y ago

If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt. I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.

levocardia 3y ago
Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
- teaearlgraycold 3y ago
  Well yeah. You’re measuring the output to a multi-variate function. There should be no expectation that this one output drives other occasionally correlated outputs to other functions.
- aulin 3y ago
  If I recall correctly there were some studies that actually showed endurance runners have higher type 2 diabetes risk. And the suspect cause was the diet, specifically the carb loading practice and the abuse of high sugar products during the activity. So the three categories may actually share the same baseline, insulin resistance. It was quite controversial when it emerged (see Tim Noakes story), not sure if it's more accepted these days.
  - lelanthran 3y ago
    This is very interesting to a diabetic like myself, who is slightly underweight. I've even had some people tell me I can't be diabetic because I don't have much, if any, extra fat.

trhway 3y ago

Doesn’t diabetes mean that the cells has to extract more energy from those lipid droplets instead of from the glucose pathway impacted by the diabetes? Thus in the cases of 2 and 3 those droplets is an additional significant source of energy. I also think that in the case of 1 the cells may be starving on glucose pathways (pre-diabetes), similar to 3 during the exercise and to 2 in regular situation, and that causes the over-eating while all that food doesn’t feed the cells because of the original issue and thus goes into fat for storage and into the lipid droplets way of feeding the cells to workaround the original glucose pathway issue.