As a non-biologist, interesting on the molecular work to get from vemurafenib to HRX215. Modern biochemistry for drug discovery is fascinating! Also, small sam

As a non-biologist, interesting on the molecular work to get from vemurafenib to HRX215. Modern biochemistry for drug discovery is fascinating! Also, small sample size, but the 85% hepatectomy in pig model results are interesting, where liver efficacy seems to be boosted enough to prevent systemic collapse post-surgery, at a normally lethal removal amount? That's a pretty smart experiment for "Does this drug do what we think it does, or are we misreading other results?"