3 ms·
First-in-class MKK4 inhibitors enhance liver regeneration, prevent liver failure
- axus 3y agoI appreciated seeing an article on the other end of the spectrum from the dark matter skepticism on sciencealert.com
- yesbut 3y agoSoon restaurants and bars will hand these out free, along with statins, with every cake, pie, and alcoholic beverage.
- astrange 3y agoStatins have dangerous downsides; they give some people uncontrollable anger.
- Smar 3y agoThis souns a lot like ethanol.
- astrange 3y agoMechanism is different though. Statins work by reducing cholesterol in your blood, but you need that for things like your brain. https://www.bbc.com/future/article/20200108-the-medications-that-change-who-we-are https://www.bbc.com/future/article/20200108-the-medications-...
- sva_ 3y agoIt makes some people very mellow as well.
- valec 3y agomore concerning are the effects on muscle tissue
- giantg2 3y agoTechnically they could be doing that with NAC already. But as long as people aren't binge drinking, it's not really a problem.
- nkozyra 3y agoI'm pretty sure NAC is sold at a lot of bars but it's not a liver cell regenerative.
- giantg2 3y agoYeah, but is a protective (technically a precrusor). So you are protecting the cells from destruction so that you don't need to regenerate them. I've actually never seen NAC at bars. Is there a place this is common? I think the FDA is proposing a crackdown on NAC too, but I'm not sure where that stands.
- nkozyra 3y ago> I've actually never seen NAC at bars. Never on its own, but in hangover prevention concoctions. I recall the FDA talking about cracking down but so far it hasn't seemed to manifest.
- ethbr1 3y agoAs a non-biologist, interesting on the molecular work to get from vemurafenib to HRX215. Modern biochemistry for drug discovery is fascinating! Also, small sample size, but the 85% hepatectomy in pig model results are interesting, where liver efficacy seems to be boosted enough to prevent systemic collapse post-surgery, at a normally lethal removal amount? That's a pretty smart experiment for "Does this drug do what we think it does, or are we misreading other results?"
- Pokerface777 3y agoIs this already available?
- OJFord 3y agoFourth bullet point right at the top is that they've just completed a phase 1 trial. So, outside of the trial, no.