It can, in this case our body can swap the "dangly bits" of cholesterol to something different like vitamin D. Aside from this, it also depends on the receptor

It can, in this case our body can swap the "dangly bits" of cholesterol to something different like vitamin D. Aside from this, it also depends on the receptor in question. Some receptors can accept levo and dextro molecules even though they are mirrored and therefore different shapes, while some have higher affinity for one and the other basically doesn't fit at all.