>(see for example the recent study showing no difference to placebo for ketamine under anaesthetic) Ketamine is an anaesthetic and has the same mechanism of ac

>(see for example the recent study showing no difference to placebo for ketamine under anaesthetic) Ketamine is an anaesthetic and has the same mechanism of action as inhalational anaesthetics. A trial of ketamine+anaesthetic vs placebo+anaesthetic might indicate that ketamine is no better than placebo, but equally it could indicate that general anaesthesia is an effective antidepressant. Your NMDA receptors don't particularly care whether they're being antagonised by ketamine, nitrous oxide or isoflurane. https://www.nature.com/articles/s44220-023-00140-x https://www.nature.com/articles/s44220-023-00140-x