As I understand it, the reasons for it working by itself are described here: “Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities

As I understand it, the reasons for it working by itself are described here: “Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities“, A. Szabo (2015). https://doi.org/10.3389%2Ffimmu.2015.00358 https://doi.org/10.3389%2Ffimmu.2015.00358 Central nervous system inflammation does not feel good. There are many, many known links between mental or emotional ills and inflammation. All the classical serotonin receptor 5-HT2A-activating psychedelics as well as MDMA are profoundly immunomodulatory. They reduce inflammation.