Tbh after a neuropharm PhD - Hepatocentrism makes more sense than cardiocentrism at the very least. Everything happens in the liver to some degree, more than th

Tbh after a neuropharm PhD - Hepatocentrism makes more sense than cardiocentrism at the very least. Everything happens in the liver to some degree, more than the "toxin remediation" metaphor its closer to "the entire chemicals and materials industry" Catch 22 put it better of course, > "... But come to us with a liver complaint and you can fool us for weeks. The liver, you see, is a large, ugly mystery to us. If you’ve ever eaten liver you know what I mean. We’re pretty sure today that the liver exists and we have a fairly good idea of what it does whenever it’s doing what it’s supposed to be doing. Beyond that, we’re really in the dark. After all, what is a liver?" Like if we have to choose some Centrism at all, - heart and lung are important to maintain continuous service, but can be replaced with a dumb pump and sparger basically - brains tend to overhype their own importance but the rest of the body can keep running *okay* for a while with lots of the brain removed (I.e "brain dead but still living") - kidneys, replace w dialysis, OK enough - liver, cannot be substituted except for transplants, body just doesn't work with it gone Personally I'd go for a digestive centric view: - in principle it kind of separates multicellular animals ... You have to be 3d to contain a double ended open tube - the intestine/stomach is our daily bargain with death so to speak, to prolong our own life by devouring other life - *digestion is highly responsive to autonomic arousal*, I.e. emotional qualia. Think of the stomach feeling metaphors of love, fear, rage, anticipation ... - in fact many emotions are best described *in terms of* their digegstive qualia - Digestive stuff is quite highly innervated, read about the neurobiology of guts for a great rabbit hole - etc. - and finally "guts" is already culturally establishrd, "gut feeling" "trust your gut" "has guts" etc