The problem though is that the purpose of research is to develop new information. Building a house is an engineering and construction problem, more akin to a m

The problem though is that the purpose of research is to develop new information. Building a house is an engineering and construction problem, more akin to a medical procedure, where you might want a tried and true method by an experienced practitioner. Research is similar in that you want someone with skill and knowledge doing the work. But there's a tension because in the extreme case, you could just find someone doing the same study they've done forever well and reliabily getting the same result, but that wouldn't be accomplishing the goal of research. What we have now is in between but probably closer to the latter approach, where funding agencies fund because it's likely to work in the sense of producing small p values, rather than because it generates new information. The story of Karikó is sad to me in part because it is so common, but most don't have the privilege of a historical event to underscore the problems and turn it into a fairy tale ending.