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This is a submarine research paper. They could have used a non-proprietary formulation with the same macro-ingredients but chose not to. This is NOT science tha

This is a submarine research paper. They could have used a non-proprietary formulation with the same macro-ingredients but chose not to. This is NOT science that can be replicated. Nutrition studies are noisy enough as it is. Very funny to see a closed source diet in an open access paper. It's open access because they paid the publisher, so it is a submarine ad.

xk_id 3y ago
> They could have used a non-proprietary formulation with the same macro-ingredients but chose not to. Do you have any idea how expensive it is to run high quality human trials, that meet all regulatory controls? It’s often not realistic without industry sponsors. Also the diet is not closed source. The full list of ingredients/supplements being used has been published before in other papers they’ve sponsored. I’ve written elsewhere on this submission about why this is actually a valuable contribution: https://news.ycombinator.com/item?id=39638556 https://news.ycombinator.com/item?id=39638556
- biomcgary 3y ago
  Excellent points. Just because it is financially motivated, does not mean it is false. For full disclosure, I work at a biotech company that is trying to enable motivated groups of people to participate in interventional studies of their own collective design with quantitative endpoints. The goal is to avoid the need for financially motivated groups to finance the study. Obviously, this isn't going to work for traditional drug development, but can for nutrition and nutraceuticals.
000ooo000 3y ago
What's a submarine ad/research paper? Hard to search.. I get real submarines.
- chatmasta 3y ago
  It's an allusion to Paul Graham's "submarine" essay [0], which isn't usually applied to promoting academic papers, but perhaps still makes sense here: > One of the most surprising things I discovered during my brief business career was the existence of the PR industry, lurking like a huge, quiet submarine beneath the news. (I've got no idea what a "closed source diet" is, btw) [0] https://paulgraham.com/submarine.html https://paulgraham.com/submarine.html

xk_id 3y ago

> They could have used a non-proprietary formulation with the same macro-ingredients but chose not to. Do you have any idea how expensive it is to run high quality human trials, that meet all regulatory controls? It’s often not realistic without industry sponsors. Also the diet is not closed source. The full list of ingredients/supplements being used has been published before in other papers they’ve sponsored. I’ve written elsewhere on this submission about why this is actually a valuable contribution: https://news.ycombinator.com/item?id=39638556 https://news.ycombinator.com/item?id=39638556

biomcgary 3y ago
Excellent points. Just because it is financially motivated, does not mean it is false. For full disclosure, I work at a biotech company that is trying to enable motivated groups of people to participate in interventional studies of their own collective design with quantitative endpoints. The goal is to avoid the need for financially motivated groups to finance the study. Obviously, this isn't going to work for traditional drug development, but can for nutrition and nutraceuticals.

000ooo000 3y ago

What's a submarine ad/research paper? Hard to search.. I get real submarines.

chatmasta 3y ago
It's an allusion to Paul Graham's "submarine" essay [0], which isn't usually applied to promoting academic papers, but perhaps still makes sense here: > One of the most surprising things I discovered during my brief business career was the existence of the PR industry, lurking like a huge, quiet submarine beneath the news. (I've got no idea what a "closed source diet" is, btw) [0] https://paulgraham.com/submarine.html https://paulgraham.com/submarine.html