3 ms·

> “We’re very confident based on the results that 100 micrograms is the right dose to bring into our phase three studies, as we didn’t see any more improvement

> “We’re very confident based on the results that 100 micrograms is the right dose to bring into our phase three studies, as we didn’t see any more improvement with 200 micrograms but did see additional adverse effects,” Karlin said.

toomuchtodo 3y ago
Appreciate the quote, I should’ve specified: from HN folks. Sometimes there is a delta between public guidance and others with experience. All suggested resources are welcome, use case is someone with crippling anxiety.
- kangda123 3y ago
  From for a friend, 80-100 mcg is pure bliss without the psychedelic effects kicking in too much. Do read more on how to do it properly though. Many factors can have greater impact on the experience than the actual dose.
- wyre 3y ago
  For therapeutic effects (not recreational) might recommend the smallest dose that’s accessible and scaling from there. Ex. Taking a 100mcg tab and dividing it into fourths. This will accustom your friend to the new feelings and lowing the chances of an anxiety attack and allow them a reference point if they want to do it again, increase the dose, or abstain. LSD is known to be anti-addictive so having some leftover should be considered safe.
deleted 3y ago
[deleted]
neom 3y ago
100µg does indeed seem to be the sweet spot, it also happens to be the dose I use to treat my depression. https://pubmed.ncbi.nlm.nih.gov/33059356/ https://pubmed.ncbi.nlm.nih.gov/33059356/
- aantix 3y ago
  How often do you take it?
  - neom 3y ago
    No particular schedule, I can feel when I need to. Usually something triggers my depression or anxiety, and then I sit with it for some period of time till I feel I'm ready to make peace with it. Last year 3 times, this year once so far. I should also note, I use psilocybin now, however I started with lysergic acid.

3 ms·

> “We’re very confident based on the results that 100 micrograms is the right dose to bring into our phase three studies, as we didn’t see any more improvement

by TheCoelacanth 3y ago

toomuchtodo 3y ago
Appreciate the quote, I should’ve specified: from HN folks. Sometimes there is a delta between public guidance and others with experience. All suggested resources are welcome, use case is someone with crippling anxiety.
- kangda123 3y ago
  From for a friend, 80-100 mcg is pure bliss without the psychedelic effects kicking in too much. Do read more on how to do it properly though. Many factors can have greater impact on the experience than the actual dose.
- wyre 3y ago
  For therapeutic effects (not recreational) might recommend the smallest dose that’s accessible and scaling from there. Ex. Taking a 100mcg tab and dividing it into fourths. This will accustom your friend to the new feelings and lowing the chances of an anxiety attack and allow them a reference point if they want to do it again, increase the dose, or abstain. LSD is known to be anti-addictive so having some leftover should be considered safe.
deleted 3y ago
[deleted]
neom 3y ago
100µg does indeed seem to be the sweet spot, it also happens to be the dose I use to treat my depression. https://pubmed.ncbi.nlm.nih.gov/33059356/ https://pubmed.ncbi.nlm.nih.gov/33059356/
- aantix 3y ago
  How often do you take it?
  - neom 3y ago
    No particular schedule, I can feel when I need to. Usually something triggers my depression or anxiety, and then I sit with it for some period of time till I feel I'm ready to make peace with it. Last year 3 times, this year once so far. I should also note, I use psilocybin now, however I started with lysergic acid.