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https://archive.is/oZcqu https://archive.is/oZcqu Important takeaway: If you use benzoyl peroxide creams, store them correctly. Heat turns them carcinogenic.
by itishappy 3y ago
https://archive.is/oZcqu https://archive.is/oZcqu
Important takeaway:
If you use benzoyl peroxide creams, store them correctly. Heat turns them carcinogenic.
> Proactiv’s 2.5% benzoyl peroxide cream, manufactured by Taro Pharmaceutical Industries Ltd., contained as much as 1,761 parts per million of benzene during Valisure’s stability testing, while a similar cream from Target reached 1,598 parts per million and a treatment from Estee Lauder Cos.’s Clinique hit 401 parts per million. A 10% benzoyl peroxide cream from Reckitt Benckiser Group Plc’s Clearasil initially tested just at the FDA limit, but jumped to 308 parts per million of benzene after being exposed to high temperatures for more than two weeks.
FDA says 2ppm is safe limit.
- im3w1l 3y agoppm sounds kind of the wrong thing to consider here. Like my intuition says it's the absolute amount rather than the relative abundance. It was a long time ago that I had acne but I remember with some of those creams you just needed a tiny amount. With sunscreen on the other hand, you need quite a lot since you are covering your whole body. Though if you just use it for your two week vacation it may not be a huge deal compared to the guy that is living in a sunny place and using it half the year.
- itishappy 3y agoAgreed! I wonder if 2ppm is a global limit, or one set specifically for benzoyl peroxides creams...
- im3w1l 3y agoI looked into it further and it seems "Class 1 solvents such as benzene should not be employed in the manufacture of drug substances, excipients, or drug products because of their unacceptable toxicity. The guidance notes that if benzene use is unavoidable to produce a drug product with a significant therapeutic advance, then its levels should be restricted to 2 parts per million (ppm), unless otherwise justified."