Backbone/Underscore - pre-render vs post-render on large data sets?

Just started looking into backbone and I really like it so far, but I really just have one concern related to underscore and it's templates. On our site we have the option to show results in 50/100/500 amounts, so far from the testing I've done, using underscore to post-render some json data, it seems to be pretty smooth as compared to sending the final HTML which is just dumped in using .html() or something. However I'm wondering if anyone has had experience with larger data sets like this and using underscores templating and if there are any issues I might expect? Thanks