3 ms·
We work a bit in the space focused on sleep. My non-medical (I'm not a doctor or scientist) opinion based on my exposure to the controversies and theories I've
by pedalpete 3y ago
We work a bit in the space focused on sleep.
My non-medical (I'm not a doctor or scientist) opinion based on my exposure to the controversies and theories I've looked at over the last 4 years is that Alzheimer's is not 1 disease.
Alzheimer's is diagnosed by ruling out other potential issues. Cognitive decline not related to hemorrhages, strokes, thyroid issues, etc get lumped into Alzheimer's (from my understanding).
This theory of the autoimmune system response is interesting, as it suggests why the amyloids exist, but it doesn't necessarily point to them not being part of the issue.
- dkz999 3y agoPretty sure this is correct. Seen a number of unbiased whole tissue seq studies point to 4-6 subtypes. Amyloid may be a driver in like one, same for immune, but mostly its tauopathy, age related, or vascular changes.
- Tagbert 3y agoYes, this is often mentioned in discussions of Alzheimer’s disease. It is so far defined based on symptoms, but without a true cause, there is no certainty that the is one cause.