5 ms·
Alzheimer's Might Not Be a Brain Disease, Expert Reveals
- nashashmi 3y agoPrevious discussions: 1. Chemical clears Alzheimer's protein and restores memory in mice (nature.com) [https://news.ycombinator.com/item?id=10751234 https://news.ycombinator.com/item?id=10751234] 452 points Dec 17, 2015 139 comments 2. Alzheimer’s amyloid hypothesis ‘cabal’ thwarted progress toward a cure (2019) (statnews.com) [https://news.ycombinator.com/item?id=31828509 https://news.ycombinator.com/item?id=31828509] 344 points June 21, 2022 311 comments 3. Potential fabrication in research threatens the amyloid theory of Alzheimer’s (science.org) [https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease https://www.science.org/content/article/potential-fabricatio...] 604 points July 21, 2022 259 comments 4. Experts Have Resigned from an FDA Committee over Alzheimer's Drug Approval (npr.org) [https://news.ycombinator.com/item?id=28615124 https://news.ycombinator.com/item?id=28615124] 319 points Sept 22, 2021 148 comments
- sydbarrett74 3y agoMore and more scientists are reaching a consensus that Alzheimer's is a form of diabetes, or the neuronal manifestation of T1D or T2D. TL;dr: Alzheimer's is an impairment of glucose metabolism within the brain.
- GenerWork 3y agoIs this for a whole group of mental maladies like dementia and Alzheimers, or just Alzheimers?
- nashashmi 3y agoWas that mentioned in this article? If not, link to a source.
- astrange 3y agoNo they aren't.
- ricardobeat 3y agoThere are studies in this direction, e.g. https://www.sciencedirect.com/science/article/pii/S0925443916302150 https://www.sciencedirect.com/science/article/pii/S092544391...
- c_o_n_v_e_x 3y agoAlzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/#:~:text=Type%203%20diabetes%20mellitus%20(T3DM,pathogenic%20mechanism%20of%20AD%20neurodegeneration https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/#:~:tex....
- lencastre 3y agowtf? It’s about sugar all along?
- danlugo92 3y agoalways_has_been_meme.jpg Surely this will stop people from feeding their children juiceboxes with 30 grams of sugar
- boppo1 3y agoHow do people get Alzheimer’s without type 1 or 2 diabetes? Sincere, not rhetorical.
- lupire 3y ago[flagged]
- firebaze 3y agoThis is as much clickbait as an NTSB report is emotional.
- thenerdhead 3y agoThe amazing thing about science today is we are learning so much about our immune system in such a short time now that a novel pathogen has humbled us. So many revelations are starting to provide a clearer picture to things like Alzheimer’s, RA, fibromyalgia, MS, ME/CFS, and more. The more interesting part? Immune cell-based treatments have really made their debut and things like monoclonal antibodies, msc, tregs, etc may just be the ticket.
- Gooblebrai 3y agoWhat novel pathogen?
- pedalpete 3y agoWe work a bit in the space focused on sleep. My non-medical (I'm not a doctor or scientist) opinion based on my exposure to the controversies and theories I've looked at over the last 4 years is that Alzheimer's is not 1 disease. Alzheimer's is diagnosed by ruling out other potential issues. Cognitive decline not related to hemorrhages, strokes, thyroid issues, etc get lumped into Alzheimer's (from my understanding). This theory of the autoimmune system response is interesting, as it suggests why the amyloids exist, but it doesn't necessarily point to them not being part of the issue.
- dkz999 3y agoPretty sure this is correct. Seen a number of unbiased whole tissue seq studies point to 4-6 subtypes. Amyloid may be a driver in like one, same for immune, but mostly its tauopathy, age related, or vascular changes.
- Tagbert 3y agoYes, this is often mentioned in discussions of Alzheimer’s disease. It is so far defined based on symptoms, but without a true cause, there is no certainty that the is one cause.
- virtabn 3y ago[flagged]