Not an expert in that field. I can speculate wildly that I'm not super optimistic. I can say I've seen the narrative around the field start to give way slightly

Not an expert in that field. I can speculate wildly that I'm not super optimistic. I can say I've seen the narrative around the field start to give way slightly - shifting from "genome is all you need" to "genome is not enough". The problem is that many of the interesting or urgent pathologies have no obvious (or weak) associations. Or maybe the noise level is too high. So there's got to be a piece of the puzzle we're missing, or something is getting lost in the noise. Whether a neural network can pull something out of the noise remains to be seen, but if it can't, I'm not super optimistic about our chances. Overall I'd say trying to tackle the problem at the outcome level is probably more promising right now. Even if we can find good associations, we're still lacking therapies.