3 ms·
Right that makes sense. I guess what happens in all of these scenarios is having an extra copy of one particular gene, causes it to become overexpressed, which
by im3w1l 3y ago
Right that makes sense. I guess what happens in all of these scenarios is having an extra copy of one particular gene, causes it to become overexpressed, which in turn leads to all these issues?
- thereticent 3y agoIt's actually many, many genes that are overexpressed and result in the Down syndrome phenotype. My work is with adults with DS and Alzheimer disease--in this case, triplication of the amyloid precursor protein (APP) gene on chromosome 21 nearly guarantees accelerated development of cerebral amyloid deposition compared to typically developing people. But that's just a miniscule part of the Down syndrome phenotype.