The reasons a set of heuristics and static code analysis can't do it is because the team developing it is constantly hard at work making Denuvo more difficult a

The reasons a set of heuristics and static code analysis can't do it is because the team developing it is constantly hard at work making Denuvo more difficult and annoying and significantly different every release. You may be able to automate version X of Denuvo after having cracked 5 games using that version, but version X+1 will be significantly different (but in a way that didn't require much work on Denuvo's end to change). The only way to fully automate it would be to have access to their source code, or be a literal super genius. I'm not an expert on it but my understand is that one part is basically have a VM with custom opcodes, and every opcode is randomized and the set of opcodes used is a subset of a larger pool. Then the code running in the VM is autogenerated from normal code using these confusing and randomly selected made up opcodes. And that is only 1 piece.