I think it depends on how far along you are in your product development lifecycle. If you're at the MVP stage or you're making big changes to your product regul

I think it depends on how far along you are in your product development lifecycle. If you're at the MVP stage or you're making big changes to your product regularly, then don't support IE, it'll slow iteration time in a similar (although not to the same extent) way that launching with an iPhone and Android app would. If you've got product market fit, paying users and have the bandwidth to support it then you probably should.