2 ms·
They're probably referring to the following study: https://www.nature.com/articles/s41370-024-00643-4 https://www.nature.com/articles/s41370-024-00643-4 "Chlo
by 34679 3y ago
They're probably referring to the following study:
https://www.nature.com/articles/s41370-024-00643-4 https://www.nature.com/articles/s41370-024-00643-4
"Chlormequat was detected at low concentrations in samples from 2017 through 2022, with a significant increase in concentrations for samples from 2023. We also observed high detection frequencies of chlormequat in oat-based foods. These findings and chlormequat toxicity data raise concerns about current exposure levels, and warrant more expansive toxicity testing, food monitoring, and epidemiological studies to assess health effects of chlormequat exposures in humans."
...
"Despite being approved for use on crops in Europe and parts of North America, chlormequat exhibits concerning toxicological properties, as documented in historical as well as more recently published laboratory animal studies. In the early 1980s, the impacts of chlormequat exposure on reproductive toxicity and fertility were first described by Danish pig farmers who observed reproductive declines in pigs raised on chlormequat treated grains [4]. These observations were later investigated in controlled laboratory experiments on pigs and mice, whereby female pigs fed chlormequat treated grain exhibited disrupted oestrus cycling and difficulty mating compared to animals on a control chlormequat-free diet [4]. Additionally, male mice exposed to chlormequat via diet or drinking water during development exhibited decreased fertilization capacity of sperm in vitro [5]. More recent reproductive toxicity studies on chlormequat show delayed onset of puberty, reduced sperm motility, decreased weights of male reproductive organs, and decreased testosterone levels in rats exposed during sensitive windows of development, including during pregnancy and early life [6,7,8]. Developmental toxicity studies also suggest that chlormequat exposure during pregnancy can dysregulate fetal growth and metabolism [9]. Other investigations did not find impacts of chlormequat on reproduction in female mice, male pigs, or a subsequent investigation of fertilization capacity in male mice developmentally and postnatally exposed to chlormequat [4, 10, 11]. Equivocal evidence in the toxicological literature on chlormequat may be due to differences in doses tested and outcomes measured as well as selection of model organism and the sex of laboratory animals. Consequently, further investigation is warranted."