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The researchers next turned to genomic analysis to see if any genetic changes could help explain these elevated levels. The genome-wide association study, invol
by DoreenMichele 3y ago
The researchers next turned to genomic analysis to see if any genetic changes could help explain these elevated levels. The genome-wide association study, involving data from nearly 50,000 people, linked elevated 2PY and 4PY levels to a gene that codes for an enzyme called ACMSD (aminocarboxymuconate semialdehyde decarboxylase).
The study has limitations. For one, the researchers don't have any information on the dietary niacin intake of the people in their cohorts.
Can someone explain to me why this is being described as "niacin is a problem" and not "We may have identified an obscure genetic disorder"? Because I'm failing to comprehend this.
- InSteady 3y agoThey validated the link between 2PY and 4PY levels and inflammation in large-ish cohorts (US and EU) that were not screened for the genetic defect. They also found inflammation from 4PY in some in vitro studies as well as in vivo mouse studies. The genetic defect is what lead them down this line of inquiry, but it's not the only evidence of an issue with high levels of niacin metabolites. From what I understand, anyway.