Crunchyroll used to offer a guided reading experience for some of their manga. You could probably build a tool that tags each panel and attempts to figure out

Crunchyroll used to offer a guided reading experience for some of their manga. You could probably build a tool that tags each panel and attempts to figure out the order, and then have a human editor do a validation pass. If you have enough people reading a series you can probably crowdsource the panel sequence.