> It would be good to compare this to diet and lifestyle change. I agree here but this is notoriously hard to test/coordinate. Any long term success of these

> It would be good to compare this to diet and lifestyle change. I agree here but this is notoriously hard to test/coordinate. Any long term success of these drugs (or anything else) does have to come with diet and lifestyle change though, so maybe the point is moot? Measuring degrees of lifestyle change would be even harder still. Not even thinking that lifestyle change can go the other way -- we're generally talking about improvements in eating habits or regular activity or whatever, but that stuff can also get worse! Hard to control for. I guess the first step is to invent mind control, then once we get past those silly little rules around experimenting on humans we can finally figure out the truly optimal mix of medication and lifestyle change (this is a joke).