3 ms·

Yes there is, you can just stop, what is this stupid clickbait title. There is research into whether weight regain happens, and most (over 50%) of people keep

Yes there is, you can just stop, what is this stupid clickbait title. There is research into whether weight regain happens, and most (over 50%) of people keep some weight off after getting off the semaglutide (and tirzepatide). Wrote about it here[0], and the the study linked is: https://www.epicresearch.org/articles/many-patients-maintain-weight-loss-a-year-after-stopping-semaglutide-and-liraglutide https://www.epicresearch.org/articles/many-patients-maintain... If you look at the STEP-1 and and SURMOUNT-4 trial extensions, the registered around a 6% drop in body weight after stopping. Price needs to go down and availability needs to go up, but the narrative around people regaining all their weight back after stopping is silly. Most importantly of all, people on these drugs might have a way to finally escape problems of food addiction because the effects are also psychological. That said, there are certainly side effects, the drugs aren't magic -- they don't work for everyone and they are expensive (right now), etc. The fearmongering is annoying though. Even from the article itself: > A commonly cited 2022 study funded by Novo Nordisk , the manufacturer of Wegovy and Ozempic, found that patients regained two-thirds of their lost weight a year after they stopped taking semaglutide, the main component in the medications. Wegovy is approved for obesity treatment. Ozempic is approved for Type 2 diabetes, but many people take it off-label for weight loss. So... People kept 1/3rd of the weight they lost off for a year?! This should be lauded. [0]: https://glp1.guide/content/do-people-regain-all-the-weight-lost-on-glp1-receptor-agonists/ https://glp1.guide/content/do-people-regain-all-the-weight-l...

s1artibartfast 3y ago
Pretty fascinating paper. I think it highlights how meaningless it is to talk about average outcomes. 18% regained all of their weight or more. 19% doubled their weight loss or more. I would love to see the actual distributions, but It looks like a pretty standard bell curve, which isnt surprising. What is surprising is the size of the distribution! Lots of people were changing their bodies after treatment in all kinds of ways! I would prefer diet control to Ozempic due to the potential risk of cancer, but understand that others may choose to make different tradeoffs.
- glp1guide 3y ago
  > I would prefer diet control to Ozempic due to the potential risk of cancer, but understand that others may choose to make different tradeoffs. Yeah I personally think that for many the answer is still diet/lifestyle changes and not necessarily GLP1 RAs. It's nice that there's a new option that is at least way more effective than the previous floundering people did though. The weight loss drug landscape is littered with terrible ineffective solutions.
thebigspacefuck 3y ago
It would be good to compare this to diet and lifestyle change. Does it have the same or better results for less cost? Are the people that had success long term changing their diet and lifestyle and were they capable of changing it without the drug? With any drug the benefit should clearly outweigh the risk, especially if it’s expensive. If the probability is that there is no long term benefit, that should be a factor and if lifestyle change is required for success it should be encouraged.
- glp1guide 3y ago
  > It would be good to compare this to diet and lifestyle change. I agree here but this is notoriously hard to test/coordinate. Any long term success of these drugs (or anything else) does have to come with diet and lifestyle change though, so maybe the point is moot? Measuring degrees of lifestyle change would be even harder still. Not even thinking that lifestyle change can go the other way -- we're generally talking about improvements in eating habits or regular activity or whatever, but that stuff can also get worse! Hard to control for. I guess the first step is to invent mind control, then once we get past those silly little rules around experimenting on humans we can finally figure out the truly optimal mix of medication and lifestyle change (this is a joke).

s1artibartfast 3y ago

Pretty fascinating paper. I think it highlights how meaningless it is to talk about average outcomes. 18% regained all of their weight or more. 19% doubled their weight loss or more. I would love to see the actual distributions, but It looks like a pretty standard bell curve, which isnt surprising. What is surprising is the size of the distribution! Lots of people were changing their bodies after treatment in all kinds of ways! I would prefer diet control to Ozempic due to the potential risk of cancer, but understand that others may choose to make different tradeoffs.

glp1guide 3y ago
> I would prefer diet control to Ozempic due to the potential risk of cancer, but understand that others may choose to make different tradeoffs. Yeah I personally think that for many the answer is still diet/lifestyle changes and not necessarily GLP1 RAs. It's nice that there's a new option that is at least way more effective than the previous floundering people did though. The weight loss drug landscape is littered with terrible ineffective solutions.

thebigspacefuck 3y ago

It would be good to compare this to diet and lifestyle change. Does it have the same or better results for less cost? Are the people that had success long term changing their diet and lifestyle and were they capable of changing it without the drug? With any drug the benefit should clearly outweigh the risk, especially if it’s expensive. If the probability is that there is no long term benefit, that should be a factor and if lifestyle change is required for success it should be encouraged.

glp1guide 3y ago
> It would be good to compare this to diet and lifestyle change. I agree here but this is notoriously hard to test/coordinate. Any long term success of these drugs (or anything else) does have to come with diet and lifestyle change though, so maybe the point is moot? Measuring degrees of lifestyle change would be even harder still. Not even thinking that lifestyle change can go the other way -- we're generally talking about improvements in eating habits or regular activity or whatever, but that stuff can also get worse! Hard to control for. I guess the first step is to invent mind control, then once we get past those silly little rules around experimenting on humans we can finally figure out the truly optimal mix of medication and lifestyle change (this is a joke).