Ideally we'd use just intonation for digital music, but 12-tone equal temperament is so deeply ingrained in everything that you practically have to start over f

Ideally we'd use just intonation for digital music, but 12-tone equal temperament is so deeply ingrained in everything that you practically have to start over from scratch if you want something with more than 12 notes in the octave. MPE is a pretty good first step, but you also need good support in composition software and DAWs. I know some people who compose in 41-TET using Musescore. I think it requires some plugins. One of the nice things about modular synthesis is that it uses control voltage for pitch, which is continuously variable. There's no built-in tuning system assumptions at all, even though individual modules may bring some 12-TET baggage with them. On the other hand, getting analog oscillators to track the volt-per-octave standard accurately enough that these subtle distinctions in pitch don't get lost in unintelligibility is easier said than done. 3340-based VCOs seem to do a decent job but they have to be calibrated carefully.