because there is always lower hanging fruit at that point. Even if this was the most altruistic, non-profit funded goal to solve an obscure ailment, once that

because there is always lower hanging fruit at that point. Even if this was the most altruistic, non-profit funded goal to solve an obscure ailment, once that inevitably fails - and statistically it is inevitably - all capital has been expended, your team's reputation has been spent. You go to something that has more consensus instead of your alchemy concoction nobody's ever head of and wasn't good for the one thing you made it for.