What AlphaFold is doing is essentially matching a sequence of amino acids to solved protein structures, albeit dynamically, and with some advanced constraints.

What AlphaFold is doing is essentially matching a sequence of amino acids to solved protein structures, albeit dynamically, and with some advanced constraints. In essence, it's not predicting how the protein will fold, but rather, how the protein will look once it's done folding. And in many many cases, there's no matching fold for a sequence. Also, proteins are dynamic. They interact with other proteins. They sample multiple conformations, they frequently rearrangle, or become disordered, and then re-ordered. AlphaFold is just a single snapshot. If we want to understand how proteins fold, we need more than just AlphaFold.