A lot of information flying around but if you want to see some of the studies that pointed to the loss of "lean body mass": https://www.nejm.org/doi/full/10.10

A lot of information flying around but if you want to see some of the studies that pointed to the loss of "lean body mass": https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 IMO one thing worth considering is the amount of muscle loss that occurs during regular rapid weight loss -- not enough studies have done comparison (I assume since it's very hard to induce the latter state). It is interesting to think about the possibility that rather than decreasing the amount people go to the gym, GLP1 Receptor Agonists (Ozempic, Wegovy, Mounjaro, Zepbound, etc) might increase it. I've written a little bit about this here[0], and while I don't always cite YouTube doctors, Doctor Mike Hansen has a pretty good evidence-heavy take[1]. For example one thing he gets into is that Tirzepatide (ex. Zepbound, Mounjaro -- the only one FDA approved for weight control) is more successful at fat loss relative to Semaglutide (ex. Ozempic, Wegovy, Rybelsus). [0]: https://glp1.guide/content/can-glp1-drugs-replace-diet-and-exercise-ozempic-mounjaro-wegovy/ https://glp1.guide/content/can-glp1-drugs-replace-diet-and-e... [1]: https://www.youtube.com/watch?v=ScBx37MBZ2s https://www.youtube.com/watch?v=ScBx37MBZ2s