3 ms·
Have there been any new developments since the rabbit kidney? https://en.wikipedia.org/wiki/Cryopreservation#Vitrification https://en.wikipedia.org/wiki/Cryopr
by chasil 3y ago
Have there been any new developments since the rabbit kidney?
https://en.wikipedia.org/wiki/Cryopreservation#Vitrification https://en.wikipedia.org/wiki/Cryopreservation#Vitrification
"Mixtures of cryoprotectants and the use of ice blockers have enabled the 21st Century Medicine company to vitrify a rabbit kidney to −135 °C with their proprietary vitrification mixture. Upon rewarming, the kidney was transplanted successfully into a rabbit, with complete functionality and viability, able to sustain the rabbit indefinitely as the sole functioning kidney."
EDIT: I will pull the PDF for the book later today.
- porejide 3y agoHere is a timeline of developments in the space over time, created by Mati Roy: https://timelines.issarice.com/wiki/Timeline_of_brain_preservation https://timelines.issarice.com/wiki/Timeline_of_brain_preser...
- chasil 3y agoI'd actually be encouraged to see donated organs cryopreserved, and used for transplant long after their unpreserved expiry. When we are using cryopreserved organs, then preserving the brain becomes more obviously pragmatic. I am guessing that cryopreserved human kidneys do not have uniform cooling, spoiling interior tissue. A rabbit kidney is much smaller, and wouldn't suffer as much from this problem.
- porejide 3y agoThis is currently happening with ovarian tissue: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558345/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558345/
- Turing_Machine 3y agoHmm... maybe it would work better if you actually circulated chilling liquid through it, rather than just sticking it in a freezer. The interior veins and arteries of a kidney look like it would be a reasonably good heat exchanger.